Dormicum (midazolam) possesses an efficient tranquilizer and hypnotic action. The medicine is also characterized through an anxiolytic, anticonvulsant and relaxant effect. Following the use of this medicine, the patient may not remember the last events that occurred throughout the most intense action of the active substance. Where to Buy Dormicum (Midazolam) Online? In Our Online Pharmacy!
- Sedation with preservation of consciousness before physical investigations or medical procedures, produced under local anesthesia or without it.
- Premedication before anesthesia.
- As an induction agent for inhaled anesthetics or as a sedative for combined anesthesia, including total intravenous anesthesia.
- Ataralgesia together with ketamine for children (intramuscularly).
- Prolonged sedation in intensive care.
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- Allergic reaction to benzodiazepines or to any component of the drug.
- Pregnancy and breast-feeding
Benzodiazepines are not recommended for use during pregnancy, unless they have a safer alternative. The use of the drug in the last trimester of pregnancy or in large doses during the first stage leads to perturbations of the heart rhythm in the fetus, hypotension, hypothermia and mild respiratory depression in the newborn. Additionally, in children, whose mothers in the late period of pregnancy have been receiving benzodiazepines for a long time, a physical addiction may be formed with a certain risk of the withdrawal syndrome in the postnatal period. Dormicum does penetrate the breast milk.
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Dormicum Adverse Effects
The list of most frequent adverse effects of Dormicum includes:
- Long sedation,
- Anterograde amnesia (length of which is directly connected to the dosage),
- Hostile behavior,
- Muscle tremor,
- Excitatory paroxysms,
- Dry mouth
- Skin rash,
The use of Dormikum, even in curative doses, may result in the formation of physical addiction. The abandonment of the medicine, especially abrupt, after a long intravenous use, may be complemented by a withdrawal syndrome, symptoms of which would include seizures.
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Mode of application
Dormicum is a strong tranquilizer that calls for slow administration and individual dose prescription.
In case of older patients (60 and older), the dose should be cautiously chosen, taking into account the unique factors inherent in each patient.
The dose of Dormicum is selected individually; the drug cannot be injected quickly. The beginning of sedation varies in each case in relation to the patient’s state and dosing regimen that would include rate of administration and dose size. If needed, the dosage is selected individually. The effect occurs approximately two minutes after injection, while the maximum effect is reached on average, after 2,4 minutes.
The medicine is administered intramuscularly in a dose of 0,1 – 0,15 mg per kg for five to ten minutes prior a procedure/operation. Patients in a state of more pronounced excitation can be administered up to 0,5 mg per kg of body weight. Usually, a dose of 10 mg is enough and there is no need to exceed it.
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Signs of an overdose for Dormicum are expressed, mostly, in the intensification of its clinical effects: sleepiness, confusion, stupor and muscle weakness or paradoxical arousal. Similarly to an episode of overdose with other benzodiazepines, this does not present any danger, except the patient simultaneously received other drugs depressing the CNS or alcohol. More serious symptoms include areflexia, low blood pressure, cardiovascular depression and respiratory depression, respiratory arrest and, sometimes, coma.
Generally, only vital functions need to be observed. If a case of overdose occurs during treatment, special attention should be paid to intensive therapy aimed at maintaining cardiovascular and respiratory activity. Overdose incidents can be suppressed by a benzodiazepine antagonist – Anexam (active substance – flumazenil).
Impact on driving and operating machinery
Sedation, memory loss, lack of attentiveness and impaired muscle function can negatively affect the capability to drive a car or work with machinery. Do not deal with vehicles or work with machines or any potentially harmful mechanisms until the action of the drug is completely eliminated.
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