Nitrazepam is an effective hypnotic medicine from the benzodiazepine group. It possesses anticonvulsant, calming and muscle relaxant action.
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Indications for use
This drug is used to manage sleep problems of various genesis (trouble falling asleep, recurrent early awakenings), somnambulism, various forms of convulsive seizures (including Vest syndrome), organic lesions of the CNS, mental disorders, accompanied by an increased sense of stress and anxiety, encephalopathy with epileptic manifestations, abstinence syndrome associated with alcoholism or addiction to drugs, schizophrenia (as part of combination therapy).
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The main contraindications for usage of Nitrazepam include: acute depression, severe respiratory failure, drug or alcohol addiction, severe alcohol intoxication, temporal epilepsy, acute intoxication with medicine that can express an inhibitory effect on the CNS, pregnancy and breast-feeding, allergic reaction to the components of the medicine or other drugs of this group.
Relative contraindications: cerebral as well as spinal ataxia, organic diseases of the brain, nocturnal sleep apnea, ataxia, respiratory failure, psychosis, tendency to abuse of psychoactive drugs, elderly age.
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The hypnotic effect of Nitrazepam is characterized through the inhibition of specific cells from the reticular cluster of the brain stem. It diminishes the impact of sensitive, vegetative and motor stimuli, which break the system of healthy asleep.
Under the influence of Nitrazepam, the depth and duration of sleep increases. Sleep and awakening proceed physiologically.
The anxiolytic effect of Nitrazepam is due to the action on the limbic system and is manifested through the reduction of emotional tension, alleviation of anxiety, fear, and nervousness.
The action of Nitrazepam begins 30 minutes after intake and lasts for about 6 hours.
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Like with any other medicine of this type, there is possibility for manifestation of the following adverse effects:
- Sleepiness (usually for older people or at the start of treatment),
- inability to concentrate,
- difficulties walking straight,
- gait disturbance,
- dullness of emotions,
- decrease in speed of mental and physical reactions,
- overall low mood,
- anterograde amnesia,
- myasthenia gravis,
- paradoxical reactions (hostile outbursts, suicidal behavior, muscle spasm, confusion, hallucinations, acute arousal, touchiness, anxiety, sleeplessness),
- dry mouth,
- problems with appetite,
- violations of liver function,
- changes in libido,
Allergic reactions to Nitrazepam components: hives, itching.
Other negative manifestations may include: addiction, drug dependence; hypotension; rarely – oppression of the respiratory center, impaired vision, bulimia, weight changes, tachycardia. When reducing the dose abruptly or upon discontinuation of administration – withdrawal syndrome that includes bad temper, headache, tension, anxiety, fear, tenseness, sleep problems, dysphoria, vomiting, shiver, perceptual disorders, tachycardia, convulsions, hallucinations, rarely – acute psychosis.
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Nitrazepam (Mogadon) Overdose
Manifestations of overdose include: tiredness, decreased reflexes, deafness, decreased reaction to painful stimulation, deep sleep, dysarthria, ataxia, sight problems, shivers, shortness of breath, intense weakness, hypotension, collapse , oppression of cardiac and respiratory action, coma.
Treatment includes gastric lavage, forced diuresis and activated charcoal. Also should be used treatment that deals with specific symptoms of an overdose. Flumazenil can be prescribed as a particular antagonist (usually in hospitals). Hemodialysis proved to be ineffective.
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In the process of using Nitrazepam, patients are strictly prohibited from drinking beverages that contain alcohol. This medicine shouldn’t be used for extended periods of time, unless it is prescribed by your doctor. With renal or hepatic issues and lasting treatment, it is necessary to manage the levels of hepatic enzymes.
Healing with Nitrazepam should be stopped when patients acquire such abnormal reactions as increased hostility, excitation, panic, suicidal behavior, hallucinations, muscle cramps, problems with sleep or superficial sleep.
This drug should be used throughout pregnancy in exceptional situations and only for “vital” indications.
During the usage of Nitrazepam (Mogadon), the patient should be extremely cautious when driving means of transportation and engaging in other potentially harmful activities that necessitate an increased focus and speed of reactions.
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